Midostaurin CAS 120685-11-2

Product Description:

Product Name: Midostaurin CAS NO: 120685-11-2

Synonyms:

4'-N-benzoylstaurosporine;

PKC412,9S-(9 ,10 ,11 ,13 )-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo1,2,3-gh:3',2',1'-lmpyrrolo3,4-j1,7benzodiazonin-11-yl)-N-methylbenzamide;

Cgp 41 251;

Chemical Physical Properties:

Appearance: Tan solid

Assay : Greater than or equal to 99.0 percent

Density: 1.46g/cm3

Refractive Index: 1.76

Storage Condition: Store at 2-8 degree

Solubility: Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100 percent ethanol (2.5 mg/ml), and DMF (20 mg/ml).

Safety Information:

Hazard Code: T

Risk Statements: R36/37/38

HS Code: 29329990

Midostaurin (PKC412) is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium Streptomyces staurosporeus, and is active in patients with mutations of CD135 (FMS-like tyrosine kinase 3 receptor, FLT3).

After successful Phase II clinical trials, a Phase III trial for AML has started in 2008. It is testing midostaurin in combination with daunorubicin and cytarabine. In another trial, the substance has proven ineffective in metastatic melanoma.

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• زوج من: Plitidepsin CAS 137219-37-5
• في المادة التالية : Illudin S CAS 1149-99-1